Mankhwala a Dipeptides

L-α-dipeptides (dipeptides) sanaphunzire pafupifupi zambiri ali ndi mapuloteni ndi amino zidulo.Kafukufuku woyambirira wachitika pa L-aspartyl-L-phenylalanine methylester (aspartame) ndi Ala-Gln (Lalanyl-L-glutamine) chifukwa amagwiritsidwa ntchito pazinthu zodziwika bwino zamalonda.Kuphatikiza pa izi, chifukwa chinanso chomwe ma dipeptide sanaphunzire bwino ndi chakuti kupanga dipeptide kulibe njira zopangira zopangira, ngakhale njira zingapo zamankhwala ndi chemoenzymatic zanenedwa.

Carnosine - chitsanzo cha dipeptide
Mpaka posachedwa, njira zatsopano zapangidwa zopangira dipeptide zomwe ma dipeptides amapangidwa kudzera munjira zowola.Ma dipeptides ena ali ndi mphamvu zapadera za thupi, zomwe zimawalola kuti afulumizitse kugwiritsa ntchito dipeptide m'magawo osiyanasiyana a kafukufuku wasayansi.L-α-dipeptides amapangidwa ndi chomangira chosavuta kwambiri cha peptide cha ma amino acid awiri, komabe sapezeka mosavuta makamaka chifukwa cha njira zotsika mtengo zopangira.Ma dipeptides, komabe, ali ndi ntchito zosangalatsa kwambiri, ndipo chidziwitso cha sayansi chowazungulira chikuwonjezeka.Izi zimasiya ofufuza ambiri ali ndi udindo wopanga njira zogwira mtima komanso zotsika mtengo zopanga dipeptide.Gawoli likawerengedwa mokwanira, tikuyembekezeka kuti titha kuphunzira zambiri za momwe ma peptides alili ofunika.

Dipeptides ali ndi ntchito ziwiri zofunika, zomwe ndi:
1. Chochokera ku ma amino acid
2. Dipeptide yokha

Monga chochokera ku amino zidulo, dipeptides, pamodzi ndi amino zidulo ali osiyana physiochemical katundu, koma nthawi zambiri amagawana mmene thupi zotsatira.Izi ndichifukwa choti ma dipeptides amasinthidwa kukhala ma amino acid osiyana m'zamoyo, zomwe zimakhala ndi ma physicochemical properties.Mwachitsanzo, L-glutamine (Gln) ndi labile-labile, pomwe Ala-Gin (L-alanyl-L-glutamine) imalekerera kutentha.

Chemical synthesis ya dipeptides imachitika motere:
1. Magulu onse ogwira ntchito a dipeptide amatetezedwa (kupatulapo omwe akupanga chomangira cha ma peptide amino acid).
2. Amino acid yotetezedwa ya gulu laulere la carboxyl imatsegulidwa.
3. The adamulowetsa amino asidi amachitira ndi ena otetezedwa amino asidi.
4. Magulu oteteza omwe ali mkati mwa dipeptide amachotsedwa.