Timagwiritsa ntchito makeke kuti tikulitse zomwe mumakumana nazo.Mukapitiliza kuyang'ana webusayiti iyi, mukuvomera kugwiritsa ntchito makeke.Zambiri.
Pakufunika mwachangu kuti malipoti ofufuza zamankhwala amtundu wa ma cell a mammalian akhale okhazikika komanso atsatanetsatane, ndikuwongolera bwino ndikuyesa momwe chilengedwe chimakhalira.Izi zipangitsa kuti kachitidwe ka physiology yamunthu kukhala yolondola kwambiri ndikuthandiza kuti kafukufuku apangidwenso.
Gulu la asayansi a KAUST ndi anzawo ku Saudi Arabia ndi United States adasanthula mapepala 810 osankhidwa mwachisawawa pama cell a mammalian cell.Ochepera 700 mwa iwo adayesa 1,749 zoyeserera za chikhalidwe cha ma cell, kuphatikiza zidziwitso zokhudzana ndi chilengedwe cha cell culture medium.Kuwunika kwa gululi kukuwonetsa kuti ntchito yochulukirapo ikuyenera kuchitidwa kuti pakhale kufunikira komanso kupangidwanso kwa maphunziro otere.
Limbitsani ma cell mu chofungatira choyendetsedwa molingana ndi ma protocol.Koma maselo adzakula ndi "kupuma" pakapita nthawi, kusinthanitsa gasi ndi chilengedwe chozungulira.Izi zidzakhudza malo omwe amakuliramo, ndipo zingasinthe chikhalidwe cha acidity, mpweya wosungunuka, ndi carbon dioxide.Kusintha kumeneku kumakhudza momwe maselo amagwirira ntchito ndipo angapangitse kuti thupi likhale losiyana ndi momwe thupi la munthu limakhalira.
"Kafukufuku wathu akugogomezera momwe asayansi amanyalanyaza kuyang'anira ndi kuyang'anira chilengedwe cha ma cell, komanso momwe malipoti amawathandizira kuti akwaniritse mfundo za sayansi ndi njira zenizeni," adatero Klein.
Mwachitsanzo, ofufuza adapeza kuti pafupifupi theka la mapepala owunikira adalephera kufotokoza kutentha ndi mawonekedwe a carbon dioxide m'maselo awo.Ochepera 10% adanenanso za mpweya wa mpweya mu chofungatira, ndipo ochepera 0.01% adanenanso za acidity ya sing'angayo.Palibe mapepala omwe adanenedwa za mpweya wosungunuka kapena mpweya woipa m'manyuzipepala.
Timadabwa kwambiri kuti ochita kafukufuku amanyalanyaza kwambiri zinthu zachilengedwe zomwe zimasunga magawo okhudzana ndi physiologically panthawi yonse ya chikhalidwe cha maselo, monga chikhalidwe cha acidity, ngakhale kuti zimadziwika bwino kuti izi ndizofunikira pa ntchito ya selo.”
Gululi likutsogoleredwa ndi Carlos Duarte, katswiri wa zamoyo zam'madzi ku KAUST, ndi Mo Li, katswiri wa zamoyo wa stem cell, mogwirizana ndi Juan Carlos Izpisua Belmonte, katswiri wa sayansi yachitukuko ku Salk Institute.Pakali pano ndi pulofesa woyendera ku KAUST ndipo amalimbikitsa kuti akatswiri a sayansi ya zamankhwala apange malipoti ovomerezeka Ndi njira zowongolera ndi zoyezera, kuphatikizapo kugwiritsa ntchito zida zapadera zoyendetsera chikhalidwe cha chikhalidwe cha mitundu yosiyanasiyana ya maselo.Majenali asayansi akhazikitse miyezo yoperekera malipoti ndipo amafunikira kuyang'anira kokwanira ndi kuwongolera kwa acidity ya media, mpweya wosungunuka ndi mpweya woipa.
"Kufotokozera bwino, kuyeza, ndi kuwongolera chilengedwe cha chikhalidwe cha maselo kuyenera kupititsa patsogolo luso la asayansi kubwereza ndi kutulutsa zotsatira zoyesera," akutero Alsolami."Kuyang'anitsitsa kungapangitse zinthu zatsopano zomwe zapezedwa ndikuwonjezera kufunika kwa kafukufuku wam'mbuyomu m'thupi la munthu."
"Chikhalidwe cha maselo amtundu wa mamalia ndiwo maziko opangira katemera wa ma virus ndi njira zina zopangira ma biotechnologies," akufotokoza motero wasayansi wam'madzi Shannon Klein."Asanayese nyama ndi anthu, amagwiritsidwa ntchito powerengera ma cell biology, kutengera momwe matenda amagwirira ntchito, komanso kuphunzira zakupha kwa mankhwala atsopano."
Klein, SG, etc. (2021) Kunyalanyaza kwachilengedwe kwa chilengedwe mu chikhalidwe cha ma mammalian cell kumafuna machitidwe abwino.Natural Biomedical Engineering.doi.org/10.1038/s41551-021-00775-0.
Tags: B cell, cell, cell chikhalidwe, chofungatira, mammalian cell, kupanga, oxygen, pH, physiology, preclinical, kafukufuku, T cell
M'mafunso awa, Pulofesa John Rossen adalankhula za kutsatizana kwa mibadwo yotsatira komanso momwe zimakhudzira matenda.
M'mafunso awa, News-Medical idalankhula ndi Pulofesa Dana Crawford za ntchito yake yofufuza pa nthawi ya mliri wa COVID-19.
M'mafunsowa, News-Medical idalankhula ndi Dr. Neeraj Narula za zakudya zosinthidwa kwambiri komanso momwe izi zingakulitsire chiwopsezo cha matenda otupa a m'matumbo (IBD).
News-Medical.Net imapereka zidziwitso zachipatalazi molingana ndi izi.Chonde dziwani kuti zambiri zachipatala zomwe zili patsamba lino ndizothandiza m'malo mosintha ubale pakati pa odwala ndi madotolo/madokotala komanso malangizo azachipatala omwe angapereke.
Nthawi yotumiza: Sep-07-2021
